Should you be picky about a gun caliber?

If you are set on one caliber that you know you want, stick to it. If it's a matter of, for instance, you want a Remington 700 30-06, but you find a Ruger M77 instead, you might think about changing platforms instead of calibers. I think decisions made laterally in quality should be acceptable, but certainly not for a lesser quality gun. I have found for myself that sticking to calibers I KNOW I want to use has caused me less headaches. Changing platforms has led to some pleasant surprises. An example of this would be, some years ago I wanted another 45 Colt revolver, but this time i wanted a double action revolver and set my sights on S&W model 25's, I searched high and low, everything I found was either beat up way too bad, or they wanted brand new money for used guns. I "settled" for a Ruger Redhawk 4" 45 Colt, and couldn't be happier with it! Instead of thinking about changing calibers, maybe consider changing platforms instead.